Asymmetric Hydrogenation I. Catalytic Hydrogenation of (-)-Menthyl Phenylglyoxylate
نویسندگان
چکیده
منابع مشابه
Catalytic asymmetric hydrogenation of naphthalenes.
The catalytic asymmetric hydrogenation of heteroarenes has been intensively studied during the last decade. Nowadays, various heteroaromatics, for example, indoles, pyrroles, and quinolines, can be reduced to the corresponding chiral heterocycles with high stereoselectivity through asymmetric catalysis. Glorius and co-workers recently found that a chiral N-heterocyclic carbene–ruthenium catalys...
متن کاملCatalytic Asymmetric Hydrogenation of Heteroarenes
INTRODUCTION Asymmetric hydrogenation of unsaturated organic compounds has been established as one of the most efficient methods for the preparation of chiral, non-racemic substrates. Among hydrogenation of various substrates, the asymmetric hydrogenation of heteroarenes provides a straightforward approach to a wide range of enantiomerically pure saturated heterocycles, which are subunits of ma...
متن کاملCatalytic asymmetric hydrogenation of 2,3,5-trisubstituted pyrroles.
Catalytic asymmetric hydrogenation of N-Boc-protected pyrroles proceeded with high enantioselectivity by using a ruthenium catalyst modified with a trans-chelating chiral bisphosphine PhTRAP. The ruthenium catalyst prepared from Ru(eta3-methallyl)2(cod) and (S,S)-(R,R)-PhTRAP in the presence of triethylamine was the most enantioselective for the asymmetric hydrogenation of methyl pyrrole-2-carb...
متن کاملCatalytic asymmetric hydrogenation of 3-substituted benzisoxazoles.
A variety of 3-substituted benzisoxazoles were reduced with hydrogen using the chiral ruthenium catalyst, {RuCl(p-cymene)[(R,R)-(S,S)-PhTRAP]}Cl. The ruthenium-catalyzed hydrogenation proceeded in high yield in the presence of an acylating agent, affording α-substituted o-hydroxybenzylamines with up to 57% ee. In the catalytic transformation, the N-O bond of the benzisoxazole substrate is reduc...
متن کاملAsymmetric Hydrogenation and Transfer Hydrogenation of Ketones
Optically active alcohols are important building blocks in the synthesis of fine chemicals, pharmaceuticals, agrochemicals, flavors and fragrances as well as functional materials (Arai & Ohkuma, 2011; Klingler, 2007). Furthermore, molecular hydrogen is without doubt the cleanest reducing agent, with complete atom efficiency. Therefore, the catalytic, asymmetric hydrogenation (AH) of prochiral k...
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ژورنال
عنوان ژورنال: Nippon kagaku zassi
سال: 1962
ISSN: 0369-5387,2185-0917
DOI: 10.1246/nikkashi1948.83.10_1115